[1] WELLER R O，SUBASH M，PRESTON S D，et

al. Perivascular drainage of amyloid-beta peptides

from the brain and its failure in cerebral amyloid

angiopathy and Alzheimer's disease[J]. Brain Pathol，

2008，18（2）：253-266.

[2] ILIFF J J，WANG M，LIAO Y，et al. A paravascular

pathway facilitates CSF flow through the brain

parenchyma and the clearance of interstitial

solutes，including amyloid β[J/OL]. Sci Transl Med，

2012，4（147）：147ra111. https：//doi.org/10.1126/

scitranslmed.3003748.

[3] XIE L，KANG H，XU Q，et al. Sleep drives

metabolite clearance from the adult brain[J]. Science，

2013，342（6156）：373-377.

[4] RINGSTAD G，VALNES L M，DALE A M，et al.

Brain-wide glymphatic enhancement and clearance

in humans assessed with MRI[J/OL]. JCI Insight，

2018，3（13）：e121537. https：//doi.org/10.1172/jci.

insight.121537.

[5] RINGSTAD G，VATNEHOL S A S，EIDE P K.

Glymphatic MRI in idiopathic normal pressure

hydrocephalus[J]. Brain，2017，140（10）：2691-2705.

[6] KRESS B T，ILIFF J J，XIA M，et al. Impairment of

paravascular clearance pathways in the aging brain[J].

Ann Neurol，2014，76（6）：845-861.

[7] TARASOFF-CONWAY J M，CARARE R O，

OSORIO R S，et al. Clearance systems in the brainimplications

for Alzheimer disease[J]. Nat Rev Neurol，

2015，11（8）：457-470.

[8] ILIFF J J，NEDERGAARD M. Is there a cerebral

lymphatic system? [J]. Stroke，2013，44（6 Suppl 1）：

S93-S95.

[9] DA MESQUITA S，LOUVEAU A，VACCARI A，et

al. Functional aspects of meningeal lymphatics in

ageing and Alzheimer's disease[J]. Nature，2018，560

（7717）：185-191.

[10] LEE H，XIE L，YU M，et al. The effect of body

posture on brain glymphatic transport[J]. J Neurosci，

2015，35（31）：11034-11044.

[11] KIVINIEMI V，WANG X，KORHONEN V，et al.

Ultra-fast magnetic resonance encephalography of

physiological brain activity-Glymphatic pulsation

mechanisms?[J]. J Cereb Blood Flow Metab，2016，36

（6）：1033-1045.

[12] QIU C，SIGURDSSON S，ZHANG Q，et al. Diabetes，

markers of brain pathology and cognitive function：

the Age，Gene/Environment Susceptibility-Reykjavik

Study[J]. Ann Neurol，2014，75（1）：138-146.

[13] PENG W，ACHARIYAR T M，LI B，et al.

Suppression of glymphatic fluid transport in a mouse

model of Alzheimer's disease[J/OL]. Neurobiol

Dis，2016，93：215-225. https：//doi.org/10.1016/

j.nbd.2016.05.015.

[14] YAFFE K，BLACKWELL T，KANAYA A M，et al.

Diabetes，impaired fasting glucose，and development

of cognitive impairment in older women[J]. Neurology，

2004，63（4）：658-663.

[15] ZHANG L，CHOPP M，ZHANG Y，et al. Diabetes

mellitus impairs cognitive function in middle-aged

rats and neurological recovery in middle-aged rats

after stroke[J]. Stroke，2016，47（8）：2112-2118.

[16] JIANG Q，ZHANG L，DING G，et al. Impairment

of the glymphatic system after diabetes[J]. J Cereb

Blood Flow Metab，2017，37（4）：1326-1337.